Antiemetic

⚠️ PCP and ACP: requires BCEHS-specific education

Relief of moderate to severe nausea and vomiting

• Known allergy or hypersensitivity to ondansetron
• Congenital long QT syndrome
•  Phenylketonuria (PKU)- Ondansetron ODT may contain aspartame which should be avoided in patients with phenylketonuria. Ondansetron injection can be safely administered in this population.
• Relative contraindication in first trimester pregnancy- clinicall consultation REQUIRED in all pregnant patients
• Please note that some Indigenous people may have a higher prevalence of Long QT Syndrome due to a genetic variation. It is advisable to inquire with Indigenous patients whether they or their family have been diagnosed with Long QT Syndrome. If so, dimenhyDRINATE is the recommended antiemetic for this patient population.

Parenteral:

• Onset: 15-30 minutes
• Peak: 1 hour
• Duration: > 5 hours

• Hypotension
• Depression or agitation

Carefully assess patients prior to administering ondansetron.  Evaluate the type and intensity of the nausea, as well as the efficacy of relief following administration.  Closely monitor patients for signs of respiratory depression or CNS effects, particularly in elderly patients or those with hepatic or renal impairment.