CCP: Generalized tonic-clonic seizure, partial seizures, myoclonic epilepsy
CCP: Partial and generalized seizures
CCP: Status epilepticus
CCP: All indications
Precise mechanism is unknown. Anticonvulsant activity is thought to occur because of inhibition of voltage-dependant N-type calcium channels. Keppra may also bind to synaptic proteins that modulate neurotransmitter release. Displacement of negative modulators may facilitate a GABA inhibitory response.
Peak plasma time: 4 hours oral, 5-30 minutes IV
Half-life: 6-8 hours