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Isoproterenol

Classification

Stimulates beta-1 and beta-2 adrenergic receptors.

Indications

CCP: Symptomatic bradycardia

CCP: Adams-Stokes

CCP: Heart block

Contraindications

Hypersensitivity
Hypersensitivity to sulfites
Tachyarrhythmias
Ventricular arrhythmias on inotropic support
Digitalis toxicity

Caution

Renal disease
Seizure disorders
CAD
HTN
Diabetes mellitus
Hyperthyroidism
Elderly patients

Adult dosages

CCP: Bradycardia

2-10 mcg/minute IV

CCP: Heart block

2-20 mcg/minute IV

CCP: Adams-Stokes

2-20 mcg/minute IV

Pediatric Considerations And Dosing

CCP: Heart block

0.05-2 mcg/kg/minute IV

Mechanism Of Action

Strong Beta-1 and Beta-2 effects resulting in relaxation of the GI, bronchial, and uterine smooth muscle. It may also cause vasodilation of the peripheral vasculature. It causes an increase in heart rate and contractility.

Pharmacokinetics

Half-life: 2.5-5 minutes

Duration: 10-15 minutes

Adverse Effects

Adams-Stokes attacks
Paradoxical heart block
Pulmonary edema
Ventricular arrhythmias
Tachycardia
HTN
Hypotension
Nervousness
Headaches
Dizziness
Nausea
Blurred vision
Flushing
Weakness
Pallor
Palpitations
Angina

Warning And Precautions

Caution advised during pregnancy; risk of fetal harm is not expected based on limites human data.
Caution advised for use while breast feeding as, no human data is available.
No longer recommended for cardiac arrest.
May cause a thyroid storm in susceptible patients with hyperthyroidism.
May transiently increase blood glucose levels.
A few patients with organic AV node disease have had a paradoxical heart block or worsening of the heart block.

Drug Interactions

Cabergoline
Dihydroergotamine
Ergotamine
Ergoloid mesylates
Isocarboxazid
Linezolid
Methylergonovine
Phenelzine
Procarbazine
Selegiline
Tranylcypromine
Yohimbe
Amitriptyline
Amoxapine
Clomipramine
Desflurane
Desipramine
Doxapram
Doxepin
Ether
Imipramine
Isoflurane
Lofepramine
Maprotiline
Methoxyflurane
Nortriptyline
Ozanimod
Protriptyline
Sevoflurane
Trazadone
Trimipramine

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Licence Level Filtering

Isoproterenol

Classification

Indications

Contraindications

Adult dosages

Pediatric Considerations And Dosing

Mechanism Of Action

Pharmacokinetics

Adverse Effects

Warning And Precautions

Drug Interactions