Blood Product Derivative; Immune Globulin

CCP: Guillain-Barré, Lambert-Eaton myasthenia gravis, myasthenia gravis, immune thrombocytopenia, Kawasaki syndrome

• Hypersensitivity
• IgA deficiency
• Hyperprolinemia
• Hypersensitivity to corn
• Hereditary intolerance to fructose
• Hypersensitivity to hyaluronidase, albumin, or any component of hyaluronidase formulation.

Onset of action: IV: Provides immediate antibody levels.

Initial response: 1 to 3 days

Peak response: 2 to 7 days

Half-life: Variable: 14-24 days

Duration: IM, IV: Immune effect: 3 to 4 weeks 

Cardiovascular:

• Chest pain, decreased heart rate, hypertension, hypotension, tachycardia.
• Flushing, heart murmur, peripheral edema

Dermatologic:

• Ecchymoses, injection site pruritus
• Allergic dermatitis, dermatitis, eczema, erythema of skin, excoriation of skin, hyperhidrosis, pruritus, skin rash, urticaria, xeroderma

Endocrine & metabolic:

• Dehydration, increased lactate dehydrogenase, thyroiditis

Gastrointestinal:

• Abdominal pain, diarrhea, nausea, upper abdominal pain, viral gastroenteritis, vomiting
• Abdominal distention, aphthous stomatitis, dyspepsia, flatulence, gastritis, stomach discomfort

Genitourinary:

• Cystitis, dysuria, urinary tract infection

Hematologic & oncologic:

• Anemia, hemolysis, positive direct Coombs test
• Bruise, hematoma, hemolytic anemia, leukopenia

Hepatic:

• Increased serum alanine aminotransferase, increased serum alkaline phosphatase, increased serum bilirubin (increased direct serum bilirubin or increased indirect serum bilirubin)
• Increased serum aspartate aminotransferase

Immunologic:

• Antibody development
• Hypersensitivity reaction
• Influenza, viral infection

Local:

• Bruising at injection site, erythema at injection site, injection site nodule, irritation at injection site, pain at injection site, swelling at injection site
• Induration at injection site, inflammation at injection site

Nervous system:

• Chills, dizziness, fatigue, headache, increased body temperature, pain, rigors
• Depression, falling, fibromyalgia syndrome (exacerbation), hypertonia, lethargy, malaise, migraine, myasthenia, sensation of cold, vertigo

Neuromuscular and skeletal:

• Asthenia, back pain, limb pain, myalgia
• Arthralgia, joint effusion, joint swelling, muscle spasm, neck pain

Respiratory:

• Asthma, bronchitis, cough, epistaxis, nasal congestion, nasopharyngitis, pharyngitis, rhinitis, sinusitis (including acute sinusitis), upper respiratory tract infection, wheezing.
• Dyspnea, flu-like symptoms, oropharyngeal pain, pharyngolaryngeal pain, pneumonia, viral upper respiratory tract infection.

Miscellaneous:

• Fever

• Thrombosis may occur with immune globulin products.
• Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur in predisposed patients with immune globulin intravenous (IGIV) products.
• Placental transfer of human IgG is dependent upon the IgG subclass and gestational age, generally increasing as pregnancy progresses.
• Immune globulin is endogenous to breast milk.

• Estrogen Derivatives
• Vaccines (live)