General anesthetic
CCP: Induction of general anesthesia
CCP: Induction of general anesthesia
Induction of general anesthesia
Ultra-short-acting nonbarbiturate general anesthetic (benzylimidazole) used for rapid induction of anesthesia with minimal cardiovascular effects; produces EEG burst suppression at high doses.
Onset of action: 30 to 60 seconds
Peak effect: 1 minute
Duration: Dose dependent: 2 to 3 minutes (0.15 mg/kg dose); 3 to 5 minutes (0.3 mg/kg dose); rapid recovery is due to rapid redistribution
Metabolism: Hepatic and plasma esterases
Half-life elimination: Terminal: 2.6 to 3.5 hours
Time to peak, serum: 7 minutes
Central nervous system: Myoclonus
Endocrine & metabolic: Adrenal suppression
Gastrointestinal: Nausea, vomiting (on emergence from anesthesia)
Local: Pain at injection site
Neuromuscular & skeletal: Musculoskeletal disease (transient skeletal movements)
Ophthalmic: Nystagmus
Gastrointestinal: Hiccups
<1%, postmarketing, and/or case reports: Apnea, bradycardia, cardiac arrhythmia, decreased cortisol (decreased cortisol synthesis), hypertension, hyperventilation, hypotension, hypoventilation, laryngospasm, muscle spasm (masseter; Bozeman 2002), tachycardia
Cortisol levels should be monitored.