Pediatric Age-Specific SIRS Criteria

Severe Pediatric Sepsis

Includes SIRS and two or more of the following signs of hypo-perfusion or organ dysfunction that is new and not explained by other known etiology of organ dysfunction:

• Proven need for >50% FiO₂ to maintain saturation ≥ 92%
• Need for non-elective invasive or noninvasive mechanical ventilation
• Glasgow Coma Score ≤11 
• Acute change in mental status with a decrease in Glasgow Coma Score ≥3 points from abnormal baseline

In Hospital Criteria

• Unexplained metabolic acidosis: base deficit > 5.0 mEq/L
• Increased arterial lactate > times upper limit of normal
• Oliguric: urine output <0.5 mL/kg/hr
• Core to peripheral temperature gap > 3°C
• PAO₂/FIO₂ <300 in absence of cyanotic heart disease or preexisting lung disease
• PaCO₂ >65 torr or 20 mmHg over baseline PaCO₂

References

Dellinger, R. Phillip et al, Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Critical Care Medicine, Feb.2013, Vol.41, No2.